Prof. Paolo Melchiorre

Catalysis / Light in Chemistry

Group Leader:

Paolo Melchiorre, ICREA Professor

Administrative Support:

Núria Planella

Postdoctoral Researchers:

Martin Berger / Aymeric Champion / Riccardo di Sanza / Will Hartley / Dengke Ma / Jan Vilím / Margherita Zanini

PhD Students:

Matteo Balletti / Eduardo de Pedro Beato / Adriana Faraone / Eugenio Gandolfo / Laura Kqiku / Emilien Le Saux / Davide Spinnato / Eleni Georgiou / Wei Zhou / Thomas Hin-Fung Wong

Lab. Technician:

Jose Miguel Selles Japas


The research of Prof. Melchiorre aims to connect two areas of molecular activation, photochemistry and organocatalysis, to provide new frameworks for chemical reactivity for the development of light-emitted asymmetric transformations. His group has shown that the synthetic potential of organocatalytic intermediates is not limited to the fundamental state, but can be expanded by exploring their photochemical activity, providing new synthetic routes for the preparation of chiral molecules that can not be achieved with the traditional methodologies.


Photochemical Organocatalytic Regio- and Enantioselective Conjugate Addition of Allyl Groups to Enals
Berger, M.; Carboni, D.; Melchiorre, P.
Angew. Chem. Int. Ed. 202160, 1-6

A General Organocatalytic System for Electron Donor−Acceptor Complex Photoactivation and Its Use in Radical Processes
de Pedro Beato, E.; Spinnato, D.; Zhou, W.; Melchiorre, P.
J. Am. Chem. Soc. 2021143, 12304-12314

Catalytic asymmetric C–C cross-couplings enabled by photoexcitation
Crisenza, G. E. M.; Faraone, A.; Gandolfo, E.; Mazzarella, D.; Melchiorre, P.
Nat. Chem. 202113, 575–580


Photochemical Chemoselective Alkylation of Tryptophan-Containing Peptides
Laroche, B.; Tang, X.; Archer, G.; Di Sanza, R.; Melchiorre, P.
Org. Lett. 202123 (2), 285–289

A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals
Le Saux, E.; Ma, D.; Bonilla, P.; Holden, C.; Lustosa, D.; Melchiorre, P.
Angew. Chem. Int. Ed. 202160 (10), 5357-5362


New Synthetic Methods Enabled by the Photochemistry of Organic Molecules and Their Use in Drug Discovery and Bioconjugation
Ministerio de Ciencia e Innovación | Ref: PID2019-106278GB-I00

Visible Light-Activated Photoinitiators for Applications in Domestic Coatings
ERC Proof of Concept | Ref: 8995421

Melchiorre Group
AGAUR | Ref: 2017SGR981

Light-Driven Asymmetric Organocatalysis
ERC Consolidator Grant | Ref: Grant agreement no. 681840


Theses Supervised

Eugenio Gandolfo
September 9th, 2021
Universitat Rovira i Virgili
«Light-driven Metal-catalyzed Asymmetric Transformations«

Eduardo de Pedro
October 13th, 2021
Universitat Rovira i Virgili
«New Organic Catalysts for the Photochemical Generation of Radicals«



Prof. Melchiorre receives RSC’s Pedler Award